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Gene genealogies, variation and evolution : a primer in coalescent theory / Jotun Hein, Mikkel H. Schierup, and Carsten Wiuf.

By: Contributor(s): Material type: TextTextPublication details: Oxford ; New York : Oxford University Press, [(c)2005.]Description: 1 online resource (xiii, 276 pages) : illustrationsContent type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 1423770803
  • 9781423770800
  • 9786610758982
  • 6610758980
Subject(s): Genre/Form: LOC classification:
  • QH438.4.3
Online resources:
Available additional physical forms:
Contents:
The basic coalescent -- A Y-chromosome data set -- Data and theory -- The Wright-Fisher model -- Assumptions of the Wright-Fisher model -- The number of descendants of a gene in one generation -- The geometric distribution -- The exponential distribution -- The discrete-time coalescent -- Coalescence of a sample of two genes -- Coalescence of a sample of n genes -- Example: Effect of approximations -- The continuous time coalescent -- Calculating simple quantities on a coalescent tree -- The height of a tree -- The total branch length of a tree -- The effect of sampling more sequences -- The effective population size -- The Moran model -- Robustness of the coalescent -- From genealogies to sequences -- Mathematical models of alleles -- The infinite alleles model -- The infinite sites model -- Finite sites model -- The Wright-Fisher model with mutation -- Algorithms for simulating sequence evolution -- The probability of a sample configuration -- Infinite alleles model -- Infinite sites model -- Impossible ancestral states -- Quantities related to the infinite sites model -- The number of segregating sites -- Haplotypes -- Pairwise mismatch distribution -- Estimators of [theta] and Tajima's D -- Evolutionary versus sampling variance -- Example 1: The variable S[subscript n] -- Example 2: Tajima's estimator [pi] -- Trees and topologies -- Some terminology -- The jump process and the waiting time process -- The coalescent and phylogenetic trees -- Counting trees and topologies -- Gene trees -- How to build a gene tree.
Review: "This text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. Authored by leading experts, and rich in examples and illustrations, Gene Genealogies, Variation and Evolution is highly suitable for a graduate course in statistics; population, molecular and medical genetics; and for bioscience and medicine and students studying the evolution of human population and disease. It is also a reference for bioscientists and statisticians in the pharmaceutical industry and academia."--Jacket.
Item type: Online Book
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Item type Current library Collection Call number URL Status Date due Barcode
Online Book G. Allen Fleece Library Online Non-fiction QH438.4.3 (Browse shelf(Opens below)) Link to resource Available ocm68623837\

Includes bibliographies and index.

The basic coalescent -- A Y-chromosome data set -- Data and theory -- The Wright-Fisher model -- Assumptions of the Wright-Fisher model -- The number of descendants of a gene in one generation -- The geometric distribution -- The exponential distribution -- The discrete-time coalescent -- Coalescence of a sample of two genes -- Coalescence of a sample of n genes -- Example: Effect of approximations -- The continuous time coalescent -- Calculating simple quantities on a coalescent tree -- The height of a tree -- The total branch length of a tree -- The effect of sampling more sequences -- The effective population size -- The Moran model -- Robustness of the coalescent -- From genealogies to sequences -- Mathematical models of alleles -- The infinite alleles model -- The infinite sites model -- Finite sites model -- The Wright-Fisher model with mutation -- Algorithms for simulating sequence evolution -- The probability of a sample configuration -- Infinite alleles model -- Infinite sites model -- Impossible ancestral states -- Quantities related to the infinite sites model -- The number of segregating sites -- Haplotypes -- Pairwise mismatch distribution -- Estimators of [theta] and Tajima's D -- Evolutionary versus sampling variance -- Example 1: The variable S[subscript n] -- Example 2: Tajima's estimator [pi] -- Trees and topologies -- Some terminology -- The jump process and the waiting time process -- The coalescent and phylogenetic trees -- Counting trees and topologies -- Gene trees -- How to build a gene tree.

"This text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. Authored by leading experts, and rich in examples and illustrations, Gene Genealogies, Variation and Evolution is highly suitable for a graduate course in statistics; population, molecular and medical genetics; and for bioscience and medicine and students studying the evolution of human population and disease. It is also a reference for bioscientists and statisticians in the pharmaceutical industry and academia."--Jacket.

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