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Mixed Polymeric Micelles for Osteosarcoma Therapy

By: Contributor(s): Material type: TextTextPublication details: Singapore : Bentham Science Publishers, (c)2022.Description: 1 online resource (92 pages)Content type:
  • text
Media type:
  • computer
Carrier type:
  • online resource
ISBN:
  • 9815040375
  • 9789815040371
Subject(s): Genre/Form: LOC classification:
  • RC280 .M594 2022
Online resources: Available additional physical forms:
Contents:
Title -- Copyright -- End User License Agreement -- Contents -- Foreword -- Preface -- DISCLAIMER -- FUNDING -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- Abstract -- Introduction -- 1. OSTEOSARCOMA -- 1.1. Pathophysiology -- 1.1.1. Genetic Alterations -- 1.2. Diagnosis and Treatment -- 1.2.1. Targeted Therapy -- 1.2. Challenges to Osteosarcoma Treatment -- 1.2.1. Multidrug Resistance -- 1.2.2. Active Targeting -- 2. RNA INTERFERENCE TECHNOLOGY -- 2.1. miRNAs -- 2.1. miRNA-145 -- 3. GENE THERAPY -- 3.1. Viral and Non-viral Vectors
3.1.2. Cationic Polymers -- 3.1.3. Poloxamers and Poloxamines -- 3.1.4. Micelleplexes -- 3.1.5. Physicochemical Characterization -- AIMS -- Materials and Methods -- 1. MATERIALS -- 2. CHITOSAN COMPLEXED WITH PLURONIC F68 -- 3. CHITOSAN COMPLEXED WITH PLURONICS F68 AND P123 -- 4. SYNTHESIS OF PLURONIC F68 DIACRYLATE -- 5. SYNTHESIS OF PLURONIC F68 DIACRYLATE CONJUGATED WITH PEI (F68-PEI) -- 6. CHARACTERIZATION OF THE PREPARED POLYMERIC MICELLES -- 6.1. Evaluation of Particle Size and Zeta Potential -- 6.2. 1H-NMR Spectroscopy
6.4. Transmission Electron Microscopy -- 6.5. Statistical Analysis -- Results and Discussion -- 1. CHITOSAN COMPLEXED WITH PLURONIC F68 -- 2. CHITOSAN COMPLEXED WITH PLURONICS F68 AND P123 -- 3. SYNTHESIS OF PLURONIC F68 DIACRYLATE -- 4. SYNTHESIS OF PLURONIC F68 DIACRYLATE CONJUGATED WITH PEI -- 5. PREPATION OF MIXED PLURONIC F68-PEI AND PLURONIC P123 MICELLES -- 6. MORPHOLOGICAL CHARACTERIZATION -- Conclusion -- FUTURE PERSPECTIVES -- Annex -- 1. CHITOSAN COMPLEXED WITH PLURONIC F68
ABBREVIATIONS -- LIST OF ABBREVIATIONS -- REFERENCES -- REFERENCES -- Subject Index -- Back Cover
Subject: Osteosarcoma is a rare bone tumor that has a high incidence among children and young adults. Despite recent therapeutic developments, osteosarcomastill presents major hurdles to achieving successful results, mainly due to the presence of multi-drug-resistant cells.This monograph primarily aims to provide information about the basic science behind the treatment of osteosarcoma along with experimental results for a novel formulation that overcomes multidrug resistance, and therefore, may serve as a viable treatment option. The book starts with an updated and conciseguide to the pathophysiology of the.
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Holdings
Item type Current library Collection Call number URL Status Date due Barcode
Online Book (LOGIN USING YOUR MY CIU LOGIN AND PASSWORD) Online Book (LOGIN USING YOUR MY CIU LOGIN AND PASSWORD) G. Allen Fleece Library ONLINE Non-fiction RC280.6 (Browse shelf(Opens below)) Link to resource Available on1311315043

Description based upon print version of record.

Includes bibliographies and index.

Cover -- Title -- Copyright -- End User License Agreement -- Contents -- Foreword -- Preface -- DISCLAIMER -- FUNDING -- CONSENT FOR PUBLICATION -- CONFLICT OF INTEREST -- ACKNOWLEDGEMENT -- Abstract -- Introduction -- 1. OSTEOSARCOMA -- 1.1. Pathophysiology -- 1.1.1. Genetic Alterations -- 1.2. Diagnosis and Treatment -- 1.2.1. Targeted Therapy -- 1.2. Challenges to Osteosarcoma Treatment -- 1.2.1. Multidrug Resistance -- 1.2.2. Active Targeting -- 2. RNA INTERFERENCE TECHNOLOGY -- 2.1. miRNAs -- 2.1. miRNA-145 -- 3. GENE THERAPY -- 3.1. Viral and Non-viral Vectors

3.1.1. Polymeric Micelles -- 3.1.2. Cationic Polymers -- 3.1.3. Poloxamers and Poloxamines -- 3.1.4. Micelleplexes -- 3.1.5. Physicochemical Characterization -- AIMS -- Materials and Methods -- 1. MATERIALS -- 2. CHITOSAN COMPLEXED WITH PLURONIC F68 -- 3. CHITOSAN COMPLEXED WITH PLURONICS F68 AND P123 -- 4. SYNTHESIS OF PLURONIC F68 DIACRYLATE -- 5. SYNTHESIS OF PLURONIC F68 DIACRYLATE CONJUGATED WITH PEI (F68-PEI) -- 6. CHARACTERIZATION OF THE PREPARED POLYMERIC MICELLES -- 6.1. Evaluation of Particle Size and Zeta Potential -- 6.2. 1H-NMR Spectroscopy

6.3. Fourier-Transform Infrared Spectroscopy -- 6.4. Transmission Electron Microscopy -- 6.5. Statistical Analysis -- Results and Discussion -- 1. CHITOSAN COMPLEXED WITH PLURONIC F68 -- 2. CHITOSAN COMPLEXED WITH PLURONICS F68 AND P123 -- 3. SYNTHESIS OF PLURONIC F68 DIACRYLATE -- 4. SYNTHESIS OF PLURONIC F68 DIACRYLATE CONJUGATED WITH PEI -- 5. PREPATION OF MIXED PLURONIC F68-PEI AND PLURONIC P123 MICELLES -- 6. MORPHOLOGICAL CHARACTERIZATION -- Conclusion -- FUTURE PERSPECTIVES -- Annex -- 1. CHITOSAN COMPLEXED WITH PLURONIC F68

2. SYNTHESIS OF PLURONIC F68 DIACRYLATE CONJUGATED WITH PEI -- ABBREVIATIONS -- LIST OF ABBREVIATIONS -- REFERENCES -- REFERENCES -- Subject Index -- Back Cover

Osteosarcoma is a rare bone tumor that has a high incidence among children and young adults. Despite recent therapeutic developments, osteosarcomastill presents major hurdles to achieving successful results, mainly due to the presence of multi-drug-resistant cells.This monograph primarily aims to provide information about the basic science behind the treatment of osteosarcoma along with experimental results for a novel formulation that overcomes multidrug resistance, and therefore, may serve as a viable treatment option. The book starts with an updated and conciseguide to the pathophysiology of the.

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