000			05358cam a2200493Ii 4500
001			ocn851695380
003			OCoLC
005			20240726105415.0
008			121119s2013 enk ob 001 0 eng d
040			_aIDEBK _beng _epn _erda _cIDEBK _dOCLCQ _dOCLCO _dCDX _dNT _dYDXCP _dOCLCA _dOCLCF _dOCLCO _dDEBSZ _dOCLCQ _dOCLCO _dOCLCQ _dD6H _dAGLDB _dOCLCQ _dSTF _dVTS _dTOF _dWYU _dREC _dUKAHL _dOL _dOCLCO _dOCLCA _dVLY _dOCLCO
020			_a9781848169586 _q((electronic)l(electronic)ctronic)
020			_a9781299713642 _q((electronic)l(electronic)ctronic)
050	0	4	_aRG186 _b.E887 2013
049			_aMAIN
245	1	0	_aEstrogen action, selective estrogen receptor modulators, and women's health : _bprogress and promise / _cedited by V. Craig Jordan (Georgetown University, USA).
260			_aLondon : _bImperial College Press, _c(c)2013.
300			_a1 online resource (544 pages)
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_adata file _2rda
504			_a2
505	0	0	_aAbout the Author and Editor; Contributors; Acknowledgements; Forewords Nancy Brinker Bert W. O'Malley; Introduction: The Foundation of a Career V. Craig Jordan; A NEW STRATEGY: LONG-TERM ADJUVANT TAMOXIFEN; REFERENCES; Chapter 1 A Century of Deciphering the Control Mechanisms of Estrogen Action in Breast Cancer: The Origins of Targeted Therapy and Chemoprevention V. Craig Jordan; BEGINNINGS AT THE DAWN OF THE 20TH CENTURY; LINKS BETWEEN SEX STEROIDS AND CANCER; CONCEPTUAL PROGRESS THROUGH SCIENTIFIC SERENDIPITY; A TARGET FOR TREATMENT AND PREVENTION; AN UNLIKELY THERAPEUTIC SOLUTION
505	0	0	_aTARGETING TREATMENT FOR BREAST CANCERCHEMOPREVENTION OF BREAST CANCER; MOLECULAR MECHANISMS OF ESTROGEN AND SERM ACTION; DRUG RESISTANCE TO SERMS; PARALLEL PATH OF THE PROSTATE; THE SUCCESSFUL EVOLUTION OF TARGETED ANTIHORMONAL THERAPY IN THE 20TH CENTURY AND BEYOND; ACKNOWLEDGEMENTS; REFERENCES; Chapter 2 Diethylstilbestrol: A Tragedy in Reproductive Endocrinology But a Pioneering Cancer Treatment Joan Lewis-Wambi and V. Craig Jordan; INTRODUCTION; THE HISTORY OF DES; Side Effects in Women Prescribed DES During Pregnancy (First Generation)
505	0	0	_aSide Effects in DES Daughters and Sons (Second Generation)Side Effects of DES in the Third Generation; MOLECULAR MECHANISMS OF DES ACTION; MECHANISMS OF DES-INDUCED CARCINOGENESIS; ESTROGEN (DES) THERAPY AND PROSTATE CANCER; ESTROGEN (DES) THERAPY AND BREAST CANCER; MECHANISM OF ESTROGEN-INDUCED APOPTOSIS IN BREAST CANCER; CONCLUSION; ACKNOWLEDGEMENTS; REFERENCES; Chapter 3 Oral Contraceptives and Women's Health V. Daniel Castracane and V. Craig Jordan; INTRODUCTION AND HISTORY; NONCONTRACEPTIVE BENEFITS; ADVERSE EFFECTS; NEW FORMULATIONS OF THE ESTROGEN-PROGESTIN CONTRACEPTIVES
505	0	0	_aCONTINUOUS ORAL CONTRACEPTIVESCONTRACEPTION AT MORE THAN 40 YEARS OF AGE; CLOSING THOUGHTS; REFERENCES; Chapter 4 Hormone Replacement Therapy and Women's Health Jennifer Eng-Wong, Ifeyinwa Obiorah and V. Craig Jordan; STRATEGIES IN DISEASE PREVENTION; USAGE OF ESTROGEN REPLACEMENT THERAPY, APPROVALS IN THE UNITED STATES; PREPARATION AND CONTENT OF ERT; RESULTS OF HRT RANDOMIZED TRIALS; HRT and Vascular Disease; HRT and Cancer Risk; Breast Cancer; Gynecologic Cancers; Colon Cancer; Lung Cancer; HRT and Bone Health; HRT and Menopausal Symptoms; HRT and Cognitive Function
505	0	0	_aHRT and Gallbladder DiseaseSUMMARY; Challenges of the Future; ACKNOWLEDGEMENTS; REFERENCES; Note Added in Proof; Chapter 5 Induction of Ovulation by Nonsteroidal Antiestrogens Ifeyinwa Obiorah and V. Craig Jordan; INTRODUCTION; EARLY TRIALS WITH CLOMIPHENE CITRATE; CLOMIPHENE RESISTANCE; CURRENT CLOMIPHENE THERAPY AND TREATMENT MONITORING; GESTATIONAL OUTCOME WITH CLOMIPHENE AND SIDE EFFECTS; TAMOXIFEN; TAMOXIFEN AND CLOMIPHENE INDUCTION OF OVULATION; THE USE OF TAMOXIFEN IN OVARIAN STIMULATION IN BREAST CANCER PATIENTS; CONCLUSION; ACKNOWLEDGEMENTS; REFERENCES
520	0		_aThis volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs - tamoxifen and raloxifene - are known to have saved the lives of millions of women around the world and improved the health of millions more. Estrogen is the central hormone of women's health and reproduction. The book is a journey through 40 years of discovery and success in advancing women's health, with the prospect of improved innovation through medicinal chemistry for the future.
530			_a2 _ub
650		0	_aMenopause _vPopular works.
650		0	_aMenopause _xHormone therapy.
650		0	_aWomen _xHealth and hygiene.
650	1	2	_aEstrogens _xpharmacology
650	2	2	_aEstrogen Receptor Modulators _xpharmacology
650	2	2	_aReceptors, Estrogen _xphysiology
650	2	2	_aWomen's Health
655		1	_aElectronic Books.
700	1		_aJordan, V. Craig
700	1		_q(Virgil Craig)
856	4	0	_uhttps://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=605559&site=eds-live&custid=s3260518 _zClick to access digital title | log in using your CIU ID number and my.ciu.edu password
942			_cOB _D _eEB _hRG _m2013 _QOL _R _x _8NFIC _2LOC
994			_a92 _bNT
999			_c99393 _d99393
902			_a1 _bCynthia Snell _c1 _dCynthia Snell