000			05205cam a2200541Mi 4500
001			ocn847625197
003			OCoLC
005			20240726105351.0
008			121019s2013 ctua ob 001 0 eng d
010			_a2012042874
040			_aE7B _beng _epn _erda _cE7B _dOCLCO _dOCLCF _dGPM _dEBLCP _dOCLCQ _dDEBSZ _dTEFOD _dYDXCP _dTOH _dMEU _dNT _dCUX _dOCLCQ _dLOA _dD6H _dOCLCQ _dOCLCO _dOCLCA _dAGLDB _dOCLCO _dOCLCQ _dOCLCO _dICA _dOCLCQ _dMOR _dOCLCO _dPIFAG _dZCU _dOCLCO _dOTZ _dMERUC _dOCLCO _dOCLCQ _dOCLCO _dU3W _dOCLCA _dGILDS _dOCLCO _dSTF _dWRM _dVTS _dICG _dVT2 _dOCLCQ _dTKN _dXFH _dWYU _dG3B _dJBG _dOCLCO _dA6Q _dOCLCO _dDKC _dOCLCO _dAU@ _dOCLCO _dOCLCQ _dOCLCO _dUX1 _dOCLCQ _dOCLCA _dOCLCQ _dU3G _dOCLCA _dINARC _dUKCRE _dVLY _dRECBK _dAJS _dOCLCO
020			_a9780300195187 _q((electronic)l(electronic)ctronic)
020			_a9781443412148
020			_a9781299284104
050	0	4	_aQR502 _b.F383 2013
049			_aMAIN
100	1		_aIngram, Jay. _e1
245	1	0	_aFatal flaws : _bhow a misfolded protein baffled scientists and changed the way we look at the brain / _cJay Ingram.
246	3	0	_aHow a misfolded protein baffled scientists and changed the way we look at the brain
260			_aNew Haven : _bYale University Press, _c(c)2013.
300			_a1 online resource (viii, 282 pages) : _billustrations
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_adata file _2rda
520	0		_a"Discovered and identified as the cause of mad cow disease only three decades ago, the prion is a protein molecule that, when misshapen in the brain, becomes fatal. Novel and controversial, prions have provoked a scientific revolution. They challenge the very foundations of biology: A disease-causing entity with no genetic material at all? A molecule capable of infecting, multiplying, and killing? This book recounts the birth of prion science and the imaginative detective work scientists have undertaken as they struggle to find the answers to devastating brain diseases from mad cow and Creutzfeld-Jakob disease to Parkinson's, Alzheimer's, Lou Gehrig's, and others. As in each of his best-selling books, Jay Ingram here makes complex scientific concepts accessible and shows how little-known events may have profound significance. He describes the development of prion science as a rough-and-tumble affair, with rivals, eccentrics, interfering governments, and brilliantly creative people all playing salient roles. Weaving biology, medicine, human tragedy, discovery, and bitter scientific competition into his account, he reveals the stunning potential of prion science, whose discoveries may unlock the answers to some of humankind's most destructive diseases"--Provided by publisher.
504			_a2
505	0	0	_aThe mystery of kuru : a disease like no other -- _tBarflies and flatworms : how speculation and pure chance advance a new science -- _tCannibalism : an answer guaranteed to stir things up -- _tIgor and Bill : the discoveries that bring kuru to world attention -- _tThe life of a cell : a miraculous, and often precarious, complexity -- _tThe death of a cell : by subterfuge, piracy, or out-and-out assault -- _tWhen is a virus not a virus? : when a disease-causing agent reproduces without genes -- _tCreutzfeldt-Jakob disease : waking up to the potential of a devastating affliction -- _tMagnificent molecules : the proteins that make life possible -- _tProtein origami : building the gothic cathedrals of life -- _tStanley Prusiner's Heresy : an infectious agent that's a protein and nothing but -- _tAn infectious idea : the campaign for the minds of researchers -- _tA portrait of the prion : and the experiments that point to their role in the human brain -- _tMad cow disease : the uncertain ground where politics and science intersect -- _tMad cow in humans : no barrier after all -- _tThe Americas : mad mink, then cows -- _tInto the wild : deer, elk, moose, and caribou -- _tOrigins : attempting to find where prions come from -- _tCats but not dogs : when prions jump the species barrier -- _tAlzheimer's disease : plaques and tangles but so far no prions -- _tParkinson's disease : looking more and more like a prion disease -- _tLou Gehrig's disease : the emerging picture of a prion-like process in ALS -- _tChronic traumatic encephalopathy : the athletes' plague -- _tAnd in the end ...
530			_a2 _ub
650		0	_aPrions.
650		0	_aPrion diseases.
650		0	_aHistory.
650		0	_aCentral nervous system _xInfections.
650		0	_aProteins.
650		0	_aHumanities.
650		0	_aNervous system _xDiseases.
650		0	_aCentral nervous system _xDiseases.
650		0	_aDiseases.
650	1	2	_aPrion Diseases _xphysiopathology
650	2	2	_aPrions _xhistory
650	2	2	_aPrion Diseases _xhistory
650	2	2	_aPrions _xpathogenicity
655		1	_aElectronic Books.
856	4	0	_uhttps://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=568229&site=eds-live&custid=s3260518 _zClick to access digital title | log in using your CIU ID number and my.ciu.edu password
942			_cOB _D _eEB _hQR _m2013 _QOL _R _x _8NFIC _2LOC
994			_a92 _bNT
999			_c98033 _d98033
902			_a1 _bCynthia Snell _c1 _dCynthia Snell