000			03169cam a2200397 i 4500
001			on1056246388
003			OCoLC
005			20240726105111.0
008			181010t20182018mauab ob 001 0 eng d
040			_aNT _beng _erda _epn _cNT _dOCLCO _dYDX _dOCLCO _dEBLCP _dOCLCO _dNRC _dCUT _dBNG _dOCLCA _dDEGRU _dUKAHL _dOCLCQ _dJSTOR _dOCLCQ _dOCLCO
020			_a9780674988774 _q((electronic)l(electronic)ctronic)
050	0	4	_aQR414 _b.D573 2018
049			_aMAIN
100	1		_aSkalka, Anna Marie, _e1
245	1	0	_aDiscovering retroviruses : _bbeacons in the biosphere / _cAnne Marie Skalka.
260			_aCambridge, Massachusetts : _bHarvard University Press, _c(c)2018.
300			_a1 online resource (xi, 177 pages) : _bcolor illustrations, color map
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_adata file _2rda
504			_a2
520	0		_aWhen invading a host cell, viruses seize cell machinery to make copies of their own genes. The immune system recognizes the invasion. In contrast, retroviruses colonize host cells through the process of reverse transcriptase. Retroviruses open host cell DNA and graft in their retroviral RNA, integrating into the host genome. The immune system has difficulty recognizing or ridding of foreign DNA that has become its own. Discovering Retroviruses presents the history of retrovirus discovery. Skalka illuminates retroviruses' role in evolution, human health, and disease, from the first sighting at the end of the nineteenth century to recent use in genetic engineering. Retroviral sequences in the human genome mark sites where endogenous retrovirus integrated over six million years ago. The 100,000 pieces of retrovirus DNA are remnants from germ line cell invasions and total approximately eight percent of the human genome. Through investigation of animal and human retroviral sequences, we know retroviral mutations can lead to cancers and immunodeficiencies, including HIV and leukemia. Today, researchers harness retroviruses for use in gene delivery systems and precision medicine advances. Discovering Retroviruses offers a lively perspective on stories of the major pioneers of the past century and the extraordinary roads to their discoveries, and demonstrates the growing importance of genetics to modern biomedicine.-- _cProvided by publisher.
505	0	0	_aEarly pioneers -- _tAmending the central dogma -- _tThe origin of retroviruses -- _tRetroviruses and evolution -- _tRevealing the genetic basis of cancer -- _tHIV and the AIDS pandemic.
530			_a2 _ub
650		0	_aRetroviruses.
650		0	_aRetrovirus infections.
650		0	_aViruses _xEvolution.
650		0	_aMedicine _xResearch _xHistory.
650		0	_aMedicine _xHistory.
655		1	_aElectronic Books.
856	4	0	_uhttps://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=1909662&site=eds-live&custid=s3260518 _zClick to access digital title | log in using your CIU ID number and my.ciu.edu password
942			_cOB _D _eEB _hQR. _m2018 _QOL _R _x _8NFIC _2LOC
994			_a92 _bNT
999			_c89025 _d89025
902			_a1 _bCynthia Snell _c1 _dCynthia Snell