000			03898cam a22004337i 4500
001			on1311315043
003			OCoLC
005			20240726104850.0
008			220416s2022 si o ||| 0 eng d
040			_aEBLCP _beng _erda _cEBLCP _dNT
020			_a9815040375
020			_a9789815040371 _q((electronic)l(electronic)ctronic)
050	0	4	_aRC280 _b.M594 2022
049			_aMAIN
100	1		_aMelim, Catarina. _e1
245	1	0	_aMixed Polymeric Micelles for Osteosarcoma Therapy
260			_aSingapore : _bBentham Science Publishers, _c(c)2022.
300			_a1 online resource (92 pages)
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_adata file _2rda
500			_aDescription based upon print version of record.
504			_a2
505	0	0	_aCover -- _tTitle -- _tCopyright -- _tEnd User License Agreement -- _tContents -- _tForeword -- _tPreface -- _tDISCLAIMER -- _tFUNDING -- _tCONSENT FOR PUBLICATION -- _tCONFLICT OF INTEREST -- _tACKNOWLEDGEMENT -- _tAbstract -- _tIntroduction -- _t1. OSTEOSARCOMA -- _t1.1. Pathophysiology -- _t1.1.1. Genetic Alterations -- _t1.2. Diagnosis and Treatment -- _t1.2.1. Targeted Therapy -- _t1.2. Challenges to Osteosarcoma Treatment -- _t1.2.1. Multidrug Resistance -- _t1.2.2. Active Targeting -- _t2. RNA INTERFERENCE TECHNOLOGY -- _t2.1. miRNAs -- _t2.1. miRNA-145 -- _t3. GENE THERAPY -- _t3.1. Viral and Non-viral Vectors
505	0	0	_a3.1.1. Polymeric Micelles -- _t3.1.2. Cationic Polymers -- _t3.1.3. Poloxamers and Poloxamines -- _t3.1.4. Micelleplexes -- _t3.1.5. Physicochemical Characterization -- _tAIMS -- _tMaterials and Methods -- _t1. MATERIALS -- _t2. CHITOSAN COMPLEXED WITH PLURONIC F68 -- _t3. CHITOSAN COMPLEXED WITH PLURONICS F68 AND P123 -- _t4. SYNTHESIS OF PLURONIC F68 DIACRYLATE -- _t5. SYNTHESIS OF PLURONIC F68 DIACRYLATE CONJUGATED WITH PEI (F68-PEI) -- _t6. CHARACTERIZATION OF THE PREPARED POLYMERIC MICELLES -- _t6.1. Evaluation of Particle Size and Zeta Potential -- _t6.2. 1H-NMR Spectroscopy
505	0	0	_a6.3. Fourier-Transform Infrared Spectroscopy -- _t6.4. Transmission Electron Microscopy -- _t6.5. Statistical Analysis -- _tResults and Discussion -- _t1. CHITOSAN COMPLEXED WITH PLURONIC F68 -- _t2. CHITOSAN COMPLEXED WITH PLURONICS F68 AND P123 -- _t3. SYNTHESIS OF PLURONIC F68 DIACRYLATE -- _t4. SYNTHESIS OF PLURONIC F68 DIACRYLATE CONJUGATED WITH PEI -- _t5. PREPATION OF MIXED PLURONIC F68-PEI AND PLURONIC P123 MICELLES -- _t6. MORPHOLOGICAL CHARACTERIZATION -- _tConclusion -- _tFUTURE PERSPECTIVES -- _tAnnex -- _t1. CHITOSAN COMPLEXED WITH PLURONIC F68
505	0	0	_a2. SYNTHESIS OF PLURONIC F68 DIACRYLATE CONJUGATED WITH PEI -- _tABBREVIATIONS -- _tLIST OF ABBREVIATIONS -- _tREFERENCES -- _tREFERENCES -- _tSubject Index -- _tBack Cover
520	0		_aOsteosarcoma is a rare bone tumor that has a high incidence among children and young adults. Despite recent therapeutic developments, osteosarcomastill presents major hurdles to achieving successful results, mainly due to the presence of multi-drug-resistant cells.This monograph primarily aims to provide information about the basic science behind the treatment of osteosarcoma along with experimental results for a novel formulation that overcomes multidrug resistance, and therefore, may serve as a viable treatment option. The book starts with an updated and conciseguide to the pathophysiology of the.
530			_a2 _ub
650		0	_aOsteosarcoma _xTreatment.
655		1	_aElectronic Books.
700	1		_aFigueiras, Ana.
700	1		_aJarak, Ivana.
856	4	0	_zClick to access digital title | log in using your CIU ID number and my.ciu.edu password. _uhttpss://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=3199724&site=eds-live&custid=s3260518
942			_cOB _D _eEB _hRC. _m2022 _QOL _R _x _8NFIC _2LOC
994			_a92 _bNT
999			_c81023 _d81023
902			_a1 _bCynthia Snell _c1 _dCynthia Snell