000			02118cam a22003738i 4500
001			on1200831772
003			OCoLC
005			20240726104826.0
008			201008s2021 nyu ob 001 0 eng
010			_a2020044981
040			_aDLC _beng _erda _cDLC _dOCLCO _dYDX _dOCLCF _dNT
020			_a9781536188080 _q((electronic)l(electronic)ctronic)
042			_apcc
050	0	0	_aRC268
049			_aMAIN
245	1	0	_aP53 : _bstructure, functions and role in disease / _cMonte Stevens, editor.
300			_a1 online resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_adata file _2rda
490	0		_aGenetics - research and issues
504			_a2
520	0		_a"P53: Structure, Functions and Role in Disease discusses the role of p53 dysregulation in different hematologic neoplasms defined by the current WHO classification. The prevalence of p53 aberration, mechanisms of p53 inactivation, regulation of p53 signaling pathway, and prognostic implications of p53 dysfunction in different hematologic malignancies are reviewed. The authors also discuss the prevalence of p53 mutations in cancers and important mechanisms underlying the impact of p53 mutations such as loss of function, dominant negative effect and gain of function. Recent findings related to the p53-mediated neuroprotective effects of natural compounds at the cellular, molecular, and behavioral level in various in vitro and in vivo models of neurodegenerative diseases are described, with a focus on Alzheimer's disease"-- _cProvided by publisher.
530			_a2 _ub
650		0	_ap53 antioncogene.
650		0	_aCancer _xGenetic aspects.
655		1	_aElectronic Books.
700	1		_aStevens, Monte, _e5
856	4	0	_zClick to access digital title | log in using your CIU ID number and my.ciu.edu password. _uhttpss://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=2600327&site=eds-live&custid=s3260518
942			_cOB _D _eEB _hRC.. _m2021 _QOL _R _x _8NFIC _2LOC
994			_a92 _bNT
999			_c79624 _d79624
902			_a1 _bCynthia Snell _c1 _dCynthia Snell