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001			on1111704372
003			OCoLC
005			20240726104812.0
008			190902s2019 dcua obt 100 0 eng
040			_aNLM _beng _erda _epn _cNLM _dCUS _dEBLCP _dNT _dOCLCF _dYDX _dOCLCO _dNLM _dOCLCO _dUKAHL _dOCLCO _dOCLCA _dOCLCQ _dOCLCA _dOCLCO
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020			_a9780309488518
020			_a9780309488525 _q((electronic)l(electronic)ctronic)
020			_a9780309488549 _q((electronic)l(electronic)ctronic)
042			_apcc
043			_an-us---
050	0	4	_aQL737 _b.C374 2019
049			_aMAIN
100	1		_aJohnson, Anne Frances, _e1
245	1	0	_aCare, use, and welfare of marmosets as animal models for gene editing-based biomedical research : _bproceedings of a workshop / _cAnne Frances Johnson and Lida Anestidou, rapporteurs ; Roundtable on Science and Welfare in Laboratory Animal Use, Institute for Laboratory Animal Research, Division on Earth and Life Studies, National Academies of Sciences, Engineering, Medicine.
260			_aWashington, DC : _bNational Academies Press, _c(c)2019.
300			_a1 online resource (1 PDF file (xii, 107 pages)) : _billustrations
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_adata file _2rda
504			_a1
520	3		_aThe marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.
530			_a2 _ub
536			_aThis project was supported by the American Veterinary Medical Association; Association of Primate Veterinarians; Baylor College of Medicine; Broad Institute; Charles River Laboratories; Emory University; Genentech; GlaxoSmithKline; Indiana University; Janssen Research and Development, LLC; Japan Agency for Medical Research and Development; Johns Hopkins University; Johnson and Johnson/Janssen Pharmaceuticals; Massachusetts General Hospital; Massachusetts Institute of Technology (MIT); McGovern Institute for Brain Research at MIT; Medical College of Wisconsin; MedImmune; Merck and Company, Incorporated; National Institutes of Health (Contract No. HHSN263201800029I; Task Order HHSN26300016); National Primate Research Centers; Novartis; Pfizer Incorporated; University of Miami; University of Michigan; University of Pittsburgh; Wisconsin National Primate Research Center; and Yale University. Funding for this workshop was made possible, in part, by the U.S. Department of Agriculture through grant AP17AC000000G004 and the U.S. Food and Drug Administration through grant 5 R13 FD 005298-05. Views expressed in written workshop materials or publications and by speakers or moderators do not necessarily reflect the official policies of the U.S. Department of Health and Human Services; nor does any mention of trade names, commercial practices, or organizations imply endorsement by the U.S. government. This material is based on work supported by the National Science Foundation under Grant No. IOS-1639899. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project.
505	0	0	_aIntroduction -- _tContext for the use of marmosets as animal models -- _tEthical considerations -- _tCurrent research applications -- _tMarmoset genomics and genetic diversity -- _tMarmoset care and management -- _tFinal remarks -- _tAppendixes
650		0	_aMarmosets as laboratory animals _xMoral and ethical aspects _zUnited States _vCongresses.
650		0	_aLaboratory animals _xMoral and ethical aspects _zUnited States _vCongresses.
650		0	_aGene editing _xMoral and ethical aspects _zUnited States _vCongresses.
650		0	_aLaboratory animals.
650		0	_aCallithrix.
650		0	_aDiseases _xAnimal models.
650	1	2	_aAnimals, Laboratory
650	2	2	_aCallithrix
650	2	2	_aDisease Models, Animal
650	2	2	_aAnimal Welfare
650	2	2	_aBiomedical Research _xmethods
655		1	_aElectronic Books.
700	1		_aInstitute for Laboratory Animal Research (U.S.). _eissuing body.
700	1		_aAnestidou, Lida, _d1965- _erapporteur.
711	2		_aCare, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research (Workshop) _cWashington, D.C.)
856	4	0	_zClick to access digital title | log in using your CIU ID number and my.ciu.edu password. _uhttpss://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=2243117&site=eds-live&custid=s3260518
942			_cOB _D _eEB _hQL. _m2019 _QOL _R _x _8NFIC _2LOC
994			_a92 _bNT
999			_c78823 _d78823
902			_a1 _bCynthia Snell _c1 _dCynthia Snell