000			04289cam a2200445 i 4500
001			on1286956202
003			OCoLC
005			20240726104517.0
008			211202s2022 sz a ob 000 0 eng d
020			_a3030867056
020			_a9783030867058
029	1		_aAU@ _b000070299271
029	1		_aAU@ _b000070419128
040			_aYDX _beng _erda _epn _cYDX _dGW5XE _dEBLCP _dOCLCF _dOCLCO _dDKU _dNT _dOCLCQ _dOCLCO
049			_aSBIM
050	0	4	_aRA644 _b.F438 2022
100	1		_aCascella, Marco, _e1
245	1	0	_aFeatures and management of acute and chronic neuro-Covid /Marco Cascella, Elvio De Blasio.
260			_aCham : _bSpringer, _c(c)2022.
300			_a158 pages : _billustrations, charts : _c24 cm
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_adata file _2rda
504			_a1
505	0	0	_aPart I. Pathophysiology of COVID-19-associated neurotoxicity
505	0	0	_aAn update on preclinical findings -- _tOngoing clinical investigations -- _tPerspectives
505	0	0	_aPart II. Clinical manifestations of acute neurotoxicity
505	0	0	_aClinical features -- _tCNS complications -- _tPNS complications -- _tDiagnosis.-Management -- _tPerspectives
505	0	0	_aPart III. Neurological and psychiatric sequelae in COVID-19 survivors: Clinical features
505	0	0	_aNeurological late complications -- _tpsychological and psychiatric sequelae.-Diagnosis -- _tTools -- _tThe role of imaging -- _tPreventive strategies -- _tSocial and economic impact.-Multidisciplinary management -- _tPerspectives
520	0		_aThis book underlines how COVID-19 is a multisystem inflammatory disease and how its pathophysiology can predispose to an increased risk of neurological issues. Several scientific pieces of evidence showes the mechanisms underlying the neuroinvasive capacity of the SARS-CoV-2 through direct viral damage and indirect processes entering the CNS by different routes including the vasculature, the olfactory and trigeminal nerves, the cerebrospinal fluid, and the lymphatic system inducing a direct neurotoxicity. Furthermore, the pro-inflammatory cytokine storm and oxidative stress can induce microglial activation and damage to the blood-brain barrier, culminating in widespread neuroinflammatory process. This acute neurotoxicity is clinically expressed as anosmia and ageusia, headache, nausea and vomiting, but other neurologic manifestations such as acute cerebrovascular diseases, consciousness impairment due to encephalitis, and meningitis are also described. The PNS can also be affected by infectious damage and clinical manifestations including Guillain-Barr e syndrome, polyneuritis cranialis, and Miller Fisher Syndrome. A special issue concerns the neurocognitive dysfunction and altered consciousness manifested as delirium, agitation and confusion. Non-specific symptoms such as dizziness, seizures can accompany clinical pictures. Regardless of the admission diagnosis, a high percentage of patients discharged from ICUs develop disabilities affecting physical, cognitive and psychological activities. The symptoms such as asthenia, memory disturbances, depression, sleep disturbances, anxiety, and Post-traumatic stress disorder (PTSD), configure the so-called Post-intensive Care Syndrome (PICS). Multimodal management during the ICU stay and implementation of follow-up programs at patient discharge can reduce the incidence of this syndrome, improving the quality of life of surviving patients. In this complex scenario, a careful clinical approach through reliable diagnostic tools, and epidemiological studies aimed at evaluating the dimensions of the problem also in economic terms, is urgently needed. This book represents a valuable aid for all those healthcare professionals (intensivists, neurologist and psychiatrists, as well) involved in the management of these critically ill patients.
530			_a2 _ub
650		0	_aCOVID-19 (Disease) _xPathophysiology.
650		0	_aNeurologic manifestations of general diseases.
650		0	_aNeurologic Manifestations.
655		4	_aMEDICAL.
700	1		_aDe Blasio, Elvio, _e1
942			_cNUR _eAMAZON _hRA _i2021-2022 _k129.59 _m2022 _nNURS _O112-6793931-0707467 _RNURSING DEPARTMENT _2lcc
999			_c69159 _d69159
902			_a1 _bCynthia Snell _c1 _dCynthia Snell