000			03132cam a2200385 i 4500
001			on1231958172
003			OCoLC
005			20240726104516.0
008			210504s2022 njua b 001 0 eng
010			_a2021021071
015			_aGBC191430 _2bnb
016	7		_a020218913 _2Uk
020			_a9781800610118
029	1		_aUKMGB _b020218913
040			_aDLC _beng _erda _cDLC _dOCLCF _dUKMGB _dDLC _dOCLCO _dSBI
042			_apcc
049			_aSBIM
050	0	4	_aRC523 _b.A494 2022
100	1		_aKulasiri, Don, _e1
245	1	0	_aAlzheimer's disease : _bbiology, biophysics and computational models / _cDon Kulasiri, Lincoln University, New Zealand, Jingyi Liang, UiT The Arctic University of Norway, Norway.
260			_aNew Jersey : _bWorld Scientific, _c(c)2022.
300			_axv, 399 pages : _billustrations (some color) ; _c24 cm
336			_atext _btxt _2rdacontent
337			_aunmediated _bn _2rdamedia
338			_avolume _bnc _2rdacarrier
504			_a2
505	0	0	_aChapter 1. Introduction to Alzheimer's Disease -- _tChapter 2. Neuron and Its Environment as Complex Dynamic Systems -- _tChapter 3. Initiation of Action Potential: Biochemistry, Biophysics, and Relevance to AD -- _tChapter 4. Computational Biophysics of Protein Interactions in the AIS -- _tChapter 5. Computational Modeling of Presynaptic Mechanisms -- _tChapter 6. Role of Calcium in AD, Related Pathways and Hypotheses -- _tChapter 7. Biophysics of AB and Computational Modeling -- _tChapter 8. Computational Modeling of Fluxes in ER -- _tChapter 9. Dynamics of CaMKII under AD Conditions -- _tChapter 10. Quantification of Synaptic Plasticity Towards Better Understanding of AD.
520	0		_a"Alzheimer's disease (AD) is the leading cause of dementia and, unfortunately, remains incurable. The social, emotional and financial implications of AD are immeasurable, and about 47 million people worldwide are affected by AD or other forms of dementia. As lifespans are improved by healthcare systems worldwide, age-associated neurodegenerative diseases are imposing an increasing challenge to science. It is becoming imperative for us to understand the causes of these diseases, AD in particular, at molecular and cellular levels. Starting with the broader picture from a biological perspective, this book takes the reader through fascinating dynamics within and outside of neurons in the brain. Alzheimer's Disease: Biology, Biophysics and Computational Models help the reader to understand AD from mechanistic and biochemical perspectives at intra- and inter-cellular levels. It focuses on biochemical pathways and modeling associated with AD. Some of the recent research on biophysics and computational models related to AD are explained using context-driven computational and mathematical modeling and essential biology is discussed to understand the modeling research"--
530			_a2 _ub
650		0	_aAlzheimer's disease.
655		4	_aMEDICAL.
700	1		_aLiang, Jingyi, _e1
942			_cREF _eAMAZON _hRC _i2021-2022 _k158 _m2022 _nNURS _O112-0289871-4687422 _RNURSING DEPARTMENT _2lcc _w158.00
999			_c69150 _d69150
902			_a1 _bCynthia Snell _c1 _dCynthia Snell