000 03710cam a2200505 i 4500
001 on1125157391
003 OCoLC
005 20240725203635.0
008 191026s2019 sz a b 000 0 eng
016 7 _a101760529
_2DNLM
020 _a3030118118
_q(pa(print & electronic)rback)
020 _a9783030118112
_q(pa(print & electronic)rback)
029 0 _aNLM
_b101760529
035 _a(OCoLC)1125157391
040 _aNLM
_beng
_erda
_cNLM
_dBDX
_dSOI
_dOHX
_dS2H
_dOCLCO
_dOCLCF
_dOCLCA
_dYDX
_dOCLCO
_dSBI
042 _apcc
049 _aSBIM
050 0 4 _aRC268.Z69.M654 2019
245 0 0 _aMolecular and cell biology of cancer :
_bwhen cells break the rules and hijack their own planet /
_cRita Fior, Rita Zilhao, editors.
_hPR
260 _aCham, Switzerland :
_bSpringer,
_c(c)2019.
300 _aix, 216 pages :
_bcolor illustrations ;
_c24 cm.
336 _atext
_btxt
_2rdacontent
337 _aunmediated
_bn
_2rdamedia
338 _avolume
_bnc
_2rdacarrier
490 1 _aLearning materials in biosciences,
_x2509-6125
504 _a1
505 0 0 _aCancer-when cells break the rules and hijack their own planet /
_rRita Fior --
_tCancer as an evolutionary process /
_rLilia Perfeito --
_tCell signaling in cancer /
_rJoao T. Barata and Mariana L. Oliveiera --
_tThe cell cycle, cytoskeleton and cancer /
_rIrina S. Fonseca and Monica Bettencourt-Dias --
_tGenomic instability: DNA repair and cancer /
_rAna Rita Carlos --
_tCell metabolism in cancer: an energetic switch /
_rInes Pimenta de Castro --
_tCancer immunoediting and hijacking of the immune system /
_rVanda Povoa and Rita Fior --
_tAngiogenesis-vessels recruitment by tumor cells /
_rAna Magalhaes and Sergio Dias --
_tTumor niche disruption and metastatis: the role of Epithelial-Mesenchymal Transition (EMT) /
_rRita Zilhao and Helia Neves --
_tCase studies: molecular pathology perspective and impact on oncologic patients' management /
_rMireia Castillo-Martin and Joana Bibeiro.
520 0 _aThis textbook takes you on a journey to the basic concepts of cancer biology. It combines developmental, evolutionary and cell biology perspectives, to then wrap-up with an integrated clinical approach. The book starts with an introductory chapter, looking at cancer in a nut shell. The subsequent chapters are detailed and the idea of cancer as a mass of somatic cells undergoing a micro-evolutionary Darwinian process is explored. Further, the main Hanahan and Weinberg "Hallmarks of Cancer" are revisited. In most chapters, the fundamental experiments that led to key concepts, connecting basic biology and biomedicine are highlighted. In the book's closing section all of these concepts are integrated in clinical studies, where molecular diagnosis as well as the various classical and modern therapeutic strategies are addressed. The book is written in an easy-to-read language, like a one-on-one conversation between the writer and the reader, without compromising the scientific accuracy. Therefore, this book is suited not only for advanced undergraduates and master students but also for patients or curious lay people looking for a further understanding of this shattering disease.
530 _a2
_ub
650 0 _aCancer
_xMolecular aspects.
650 0 _aCancer
_xResearch.
650 0 _aCytology.
650 0 _aHuman genetics.
650 0 _aMetabolism.
650 0 _aMolecular biology.
650 1 2 _aCell Transformation, Neoplastic
655 0 _aBioMed
655 0 _aNursing
700 1 _aFior, Rita,
700 1 _aZilhao, Rita,
700 1 _e5
700 1 _e5
830 0 _aLearning materials in biosciences.
_x2509-6133
942 _cBK
_eGOBI
_hRC
_i2021-2022
_k115.39
_m2019
_nNURS
_RNURSING DEPARTMENT
_O349620
_2ddc
999 _c4488
_d4488
902 _a1
_bCynthia Snell
_c1
_dCynthia Snell