Primer on Multiple Sclerosis

Includes bibliographies and index.

Primer on Multiple Sclerosis was developed to provide a comprehensive overview of the clinical and basic science aspects of MS. It is designed to be of practical use to clinical neurologists, and addresses all of the major issues that may occur in the management of persons with MS. The reader is provided with the latest information on the science of MS, including immunology, genetics, epidemiology and pathology, as well as a summary of the newest directions in basic science research. Guidelines for diagnosis and appropriate use of diagnostic modalities are presented. All clinical aspects of MS are discussed, including extensive information on aspects that may be more challenging for the neurologist to manage, such as sleep disorders and pain. Disease modifying therapies, including those that are FDA approved, as well as off label and experimental therapies are discussed. Finally, there are chapters on employment and legal issues, as well as an overview of clinical trials and clinical trial outcome measures, which are helpful in reviewing the scientific literature in these areas.

Cover -- Contents -- Contributors -- Part 1 Historical Background -- 1 The History of Multiple Sclerosis: From the Age of Description to the Age of Therapy -- Part 2 Basic Science -- 2 Genetics and Epidemiology of Multiple Sclerosis -- 3 Neurophysiology of Multiple Sclerosis -- 4 Immunology of Multiple Sclerosis -- 5 Taking a Microscopic Look At Multiple Sclerosis -- Part 3 Diagnosis and Prognosis -- 6 Diagnosis of Multiple Sclerosis -- 7 Neuroimaging in Multiple Sclerosis -- 8 Cerebrospinal Fluid Profile -- 9 Evoked Potentials -- 10 Temporal and Clinical Course of Multiple Sclerosis -- 11 Outcome Measures in Multiple Sclerosis -- Part 4 Clinical Manifestations -- 12 Neuro-Ophthalmologic Manifestations of Multiple Sclerosis -- 13 Cerebellar and Brainstem Dysfunction in Multiple Sclerosis -- 14 Disorders of Mobility in Multiple Sclerosis -- 15 Management of Urinary and Bowel Dysfunction in Multiple Sclerosis -- 16 Assessment and Treatment of Sexual Dysfunction in Multiple Sclerosis -- 17 Gender and Reproductive Issues in Multiple Sclerosis -- 18 Cognitive Impairment and Mood Disturbances -- 19 Fatigue in Multiple Sclerosis -- 20 Multiple Sclerosis and Pain -- 21 Sleep Disorders in Multiple Sclerosis -- 22 Pediatric Multiple Sclerosis -- Part 5 Therapeutics -- 23 Immunomodulatory Agents for Relapsing-Remitting Multiple Sclerosis -- 24 Immunosuppressive and Novel Therapies -- 25 Complementary and Alternative Medicine in Multiple Sclerosis -- Part 6 Psychosocial Issues -- 26 Living With Multiple Sclerosis: The Psychosocial Challenges for Patients and Their Families -- 27 Employment and Career Development Considerations -- 28 Legal Planning Issues -- Part 7 Research -- 29 Issues in the Design and Interpretation of Multiple Sclerosis Clinical Trials -- 30 Basic Science in Multiple Sclerosis Research: Progress and Promise -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- X -- Y -- Z.

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