TY  - BOOK
AU  - Wood,Clive R.
TI  - Antibody drug discovery /Clive R. Wood, editor
T2  - Molecular medicine and medicinal chemistry
SN  - 9781848166295
AV  - QP519 .A585 2012
PY  - 2012///
CY  - London
PB  - Imperial College Press
KW  - Immunoenzyme technique
KW  - Antibody-drug conjugates
KW  - Immunology
KW  - Technique
KW  - Drug development
KW  - Pharmaceutical biotechnology
KW  - Immunoglobulins
KW  - Electronic Books
N1  - 2; Ch. 1. Humanization of antibodies; Olivier Leger and Jose W. Saldanha --; chapter 2. Selection and screening of antibody phage display libraries; David R. Buckler [and others] --; chapter 3. Affinity maturation approaches for antibody lead optimization; David Lowe, Trevor Wilkinson and Tristan J. Vaughan --; chapter 4. Transgenic mice rearranging human antibodies; Sean Stevens --; chapter 5. Isotype selection and Fc engineering: design and construction of fit-for-purpose therapeutic antibodies; William R. Strohl --; chapter 6. Antibody expression from bacteria to transgenic animals; Paul Stephens and Berni M. Sweeney --; chapter 7. Current trends in antibody purification and lead selection; Jie Chen and Andrew Nixon --; chapter 8. Design and application of immunoconjugates for cancer therapy; Sherif El Sheikh [and others] --; chapter 9. Dual-targeting bispecific antibodies as new therapeutic modalities for cancer; Zhenping Zhu --; chapter 10. Antibody fragments and alternate protein scaffolds; Lioudmila Tchistiakova [and others; 2; b
N2  - Monoclonal antibodies have become important treatments for cancer, inflammation and a wide range of other diseases, representing an increasing share of the most successful pharmaceutical markets. The technologies to discover these drugs have been developed by select centers of excellence in industry and academia, and are continually being fine tuned in the race to identify the best antibody-based drug candidates and accelerate their paths to patients. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field and to offer specialized perspectives to established researchers. The chapters set into context the significance of key developments and important considerations for selecting different approaches, such as antibody humanization, isotype selection, lead candidate selection criteria and protein production. All contributors to this work are experts in their fields and many have played pivotal roles in the creation of these technologies
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