TY  - BOOK
AU  - Melim,Catarina
AU  - Figueiras,Ana
AU  - Jarak,Ivana
TI  - Mixed Polymeric Micelles for Osteosarcoma Therapy
SN  - 9815040375
AV  - RC280 .M594 2022
PY  - 2022///
CY  - Singapore
PB  - Bentham Science Publishers
KW  - Osteosarcoma
KW  - Treatment
KW  - Electronic Books
N1  - Description based upon print version of record; 2; Cover --; Title --; Copyright --; End User License Agreement --; Contents --; Foreword --; Preface --; DISCLAIMER --; FUNDING --; CONSENT FOR PUBLICATION --; CONFLICT OF INTEREST --; ACKNOWLEDGEMENT --; Abstract --; Introduction --; 1. OSTEOSARCOMA --; 1.1. Pathophysiology --; 1.1.1. Genetic Alterations --; 1.2. Diagnosis and Treatment --; 1.2.1. Targeted Therapy --; 1.2. Challenges to Osteosarcoma Treatment --; 1.2.1. Multidrug Resistance --; 1.2.2. Active Targeting --; 2. RNA INTERFERENCE TECHNOLOGY --; 2.1. miRNAs --; 2.1. miRNA-145 --; 3. GENE THERAPY --; 3.1. Viral and Non-viral Vectors; 3.1.1. Polymeric Micelles --; 3.1.2. Cationic Polymers --; 3.1.3. Poloxamers and Poloxamines --; 3.1.4. Micelleplexes --; 3.1.5. Physicochemical Characterization --; AIMS --; Materials and Methods --; 1. MATERIALS --; 2. CHITOSAN COMPLEXED WITH PLURONIC F68 --; 3. CHITOSAN COMPLEXED WITH PLURONICS F68 AND P123 --; 4. SYNTHESIS OF PLURONIC F68 DIACRYLATE --; 5. SYNTHESIS OF PLURONIC F68 DIACRYLATE CONJUGATED WITH PEI (F68-PEI) --; 6. CHARACTERIZATION OF THE PREPARED POLYMERIC MICELLES --; 6.1. Evaluation of Particle Size and Zeta Potential --; 6.2. 1H-NMR Spectroscopy; 6.3. Fourier-Transform Infrared Spectroscopy --; 6.4. Transmission Electron Microscopy --; 6.5. Statistical Analysis --; Results and Discussion --; 1. CHITOSAN COMPLEXED WITH PLURONIC F68 --; 2. CHITOSAN COMPLEXED WITH PLURONICS F68 AND P123 --; 3. SYNTHESIS OF PLURONIC F68 DIACRYLATE --; 4. SYNTHESIS OF PLURONIC F68 DIACRYLATE CONJUGATED WITH PEI --; 5. PREPATION OF MIXED PLURONIC F68-PEI AND PLURONIC P123 MICELLES --; 6. MORPHOLOGICAL CHARACTERIZATION --; Conclusion --; FUTURE PERSPECTIVES --; Annex --; 1. CHITOSAN COMPLEXED WITH PLURONIC F68; 2. SYNTHESIS OF PLURONIC F68 DIACRYLATE CONJUGATED WITH PEI --; ABBREVIATIONS --; LIST OF ABBREVIATIONS --; REFERENCES --; REFERENCES --; Subject Index --; Back Cover; 2; b
N2  - Osteosarcoma is a rare bone tumor that has a high incidence among children and young adults. Despite recent therapeutic developments, osteosarcomastill presents major hurdles to achieving successful results, mainly due to the presence of multi-drug-resistant cells.This monograph primarily aims to provide information about the basic science behind the treatment of osteosarcoma along with experimental results for a novel formulation that overcomes multidrug resistance, and therefore, may serve as a viable treatment option. The book starts with an updated and conciseguide to the pathophysiology of the
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