Cover; Half Title Page; Title Page; Copyright Page; Declaration; About the Editor; Table of Contents; List of Contributors; List of Abbreviations; Preface; Chapter 1 Roles of Heat Shock Proteins in Apoptosis, Oxidative Stress, Human Inflammatory Diseases, and Cancer; Abstract; Introduction; Role of HSPS in Apoptosis; HSPS and Oxidative Stress; HSPS in Human Inflammatory Diseases (HIDS), And Cancer; Cancer; Association Between Heat Shock Proteins, Oxidative Stress, Apoptosis, Human Inflammatory Diseases (HIDS), And Cancer; Future Direction In The Use of HSPS as Therapeutic Candidates ConclusionsReferences; Chapter 2 T Cell-Mediated Chronic Inflammatory Diseases Are Candidates For Therapeutic Tolerance Induction With Heat Shock Proteins; Peripheral Tolerance Mechanisms; MHC-Associated Diseases Are T Cell-Mediated And Possible Targets For Induction of Heat Shock Protein (HSP)-Driven Therapeutic Tolerance; HSP And The Induction Of Therapeutic Tolerance; Author Contributions; References; Chapter 3 Heat Shock Proteins And Autophagy Pathways In Neuroprotection: From Molecular Bases To Pharmacological Interventions; Abstract; Introduction; Heat Shock Proteins ER-Stress, UPR, Erad, Ubiquitination, And The Ubiquitin- Proteasome System (UPS)Endo-Lysosomal System And Autophagy; Prevention And Treatment Of NDDS; Conclusions; Acknowledgments; Author Contributions; References; Chapter 4 The Heat Shock Response In Neurons and Astroglia and Its Role in Neurodegenerative Diseases; Abstract; Background; The HSR; The HSR In The Mammalian CNS; Studying The Therapeutic Effects of Increasing HSR Components; Conclusions; Acknowledgements; Authors' Contributions; References Chapter 5 Cellular Response To ELF-MF and Heat: Evidence For A Common Involvement of Heat Shock Proteins?Introduction; Chaperones-Heat Shock Proteins; ELF-MF And Heat Shock Proteins; Combined Exposure To ELF-MF and Heat; Summary And Concluding Remarks; Author Contributions; References; Chapter 6 Redox Aspects of Chaperones in Cardiac Function; Introduction; Reactive Oxygen and Nitrogen Species and Redox Signaling; Redox Regulation of Chaperone Proteins; Chaperones in The Heart; Chaperones in Cardiac Mitochondria; Chaperones in Physiological Exercise Chaperones in Myocardial Ischemia/Reperfusion Injury and CardioprotectionConclusions; Author Contributions; Acknowledgments; References; Chapter 7 Cross-Adaptation: Heat And Cold Adaptation To Improve Physiological And Cellular Responses To Hypoxia; Abstract; Introduction; Heat To Hypoxia Cross-Adaptation; Cold To Hypoxia Cross-Adaptation; Conclusions; References; Chapter 8 Molecular Chaperone Accumulation In Cancer And Decrease in Alzheimer's Disease: The Potential Roles of HSF1; Introduction; Heat Shock Proteins- An Inducible Class of Molecular Chaperones