TY  - BOOK
AU  - Fior,Rita
AU  - Zilhao,Rita
AU  - 
AU  - 
TI  - Molecular and cell biology of cancer: when cells break the rules and hijack their own planet 
T2  - Learning materials in biosciences,
SN  - 3030118118
AV  - RC268.Z69.M654 2019 
PY  - 2019///
CY  - Cham, Switzerland
PB  - Springer
KW  - Cancer
KW  - Molecular aspects
KW  - Research
KW  - Cytology
KW  - Human genetics
KW  - Metabolism
KW  - Molecular biology
KW  - Cell Transformation, Neoplastic
KW  - BioMed
KW  - Nursing
N1  - 1; Cancer-when cells break the rules and hijack their own planet; Rita Fior --; Cancer as an evolutionary process; Lilia Perfeito --; Cell signaling in cancer; Joao T. Barata and Mariana L. Oliveiera --; The cell cycle, cytoskeleton and cancer; Irina S. Fonseca and Monica Bettencourt-Dias --; Genomic instability: DNA repair and cancer; Ana Rita Carlos --; Cell metabolism in cancer: an energetic switch; Ines Pimenta de Castro --; Cancer immunoediting and hijacking of the immune system; Vanda Povoa and Rita Fior --; Angiogenesis-vessels recruitment by tumor cells; Ana Magalhaes and Sergio Dias --; Tumor niche disruption and metastatis: the role of Epithelial-Mesenchymal Transition (EMT); Rita Zilhao and Helia Neves --; Case studies: molecular pathology perspective and impact on oncologic patients' management; Mireia Castillo-Martin and Joana Bibeiro; 2; b
N2  - This textbook takes you on a journey to the basic concepts of cancer biology. It combines developmental, evolutionary and cell biology perspectives, to then wrap-up with an integrated clinical approach. The book starts with an introductory chapter, looking at cancer in a nut shell. The subsequent chapters are detailed and the idea of cancer as a mass of somatic cells undergoing a micro-evolutionary Darwinian process is explored. Further, the main Hanahan and Weinberg "Hallmarks of Cancer" are revisited. In most chapters, the fundamental experiments that led to key concepts, connecting basic biology and biomedicine are highlighted. In the book's closing section all of these concepts are integrated in clinical studies, where molecular diagnosis as well as the various classical and modern therapeutic strategies are addressed. The book is written in an easy-to-read language, like a one-on-one conversation between the writer and the reader, without compromising the scientific accuracy. Therefore, this book is suited not only for advanced undergraduates and master students but also for patients or curious lay people looking for a further understanding of this shattering disease
ER  -