Molecular aspects of the psychosomatic-metabolic axis and stress /Alfred Bennun, Ph. D.

Includes bibliographies and index.

MOLECULAR ASPECTS OF THE PSYCHOSOMATIC-METABOLIC AXIS AND STRESS; MOLECULAR ASPECTS OF THE PSYCHOSOMATIC-METABOLIC AXIS AND STRESS; Library of Congress Cataloging-in-Publication Data; Contents; Preface; Chapter 1: Methods; Mg2+-Treated Particles of Adenylyl Cyclase; Ca2+-Treated Particle Cyclase Preparation; Male Sprague-Dawley rats weighing 200g were stunned and decapitated at 4oC. Cerebral cortex from several brains were sliced and collected in a volume (4ml/cortex) of ice-cold 10mM-Tricine/Tris buffer, pH=7.4, containing 2mM-sucrose. Then, homogenized ...

The pellet was suspended of 10mM-Tricine/Tris buffer, pH=7.4, containing 0.5mM-CaCl2. The Ca2+-treated particle was used either fresh indicated in the legend, or after storage at -70oC. Thawing for 30min at room temperature (24oC). Before its experime...EDTA-Purified Membrane Preparations from Cortex, Hypothalamus and Striatum Brain Tissue; Assay of Adenylyl Cyclase; Isolation of Cells from Fat Tissue; Particulate Preparation of Adenylyl Cyclase from Adipose Tissue; Assay of the Particulate Fat Adenylyl Cyclase from Fat-Cell; Assay of cAMP; Purified Rat Liver IRTK Preparation.

Insulin Receptor Tyrosine Kinase AssayData Analysis; Chapter 2: The Biological Fundamentals of the Adrenergic System of Brain; Catecholamine Synthesis; Neurogenesis; Presynaptic; Postsynaptic; Transversal Media Cut of Brain; LC-Noradrenaline-Dependent Activation of Emotional Responsiveness; Brain Regions Afferent Signaling to Postsynaptic LC-Neurons; Serotonin; The Amygdala; Cerebral Cortex; Anterior Temporal Lobe; Hypothalamus; Arginine Vasopressin; Oxytocin; Hippocampus; Cerebellar Cortex; Memory Modulation; The Role of Amygdala in Emotional Learning and Memory.

The Role of Glucose as a Reward Mechanism for the Consolidation of Cognitive CircuitsCircadian Clock in Mammals; Chapter 3: Molecular Details of Ligand Selectivity; The role of the Ion Ca2+ in Biological Signaling Controls; The Role of the Mg2+ in Biological Signaling Controls; Nitric Oxide Synthase; The Role of Water; The Relationship of Protein Conformational Changes to Mechanisms of Energy Transduction; Chapter 4: Dynamics of Ligands Exchanges during Hb Deoxygenation; Dynamics of the Quaternary Structure of Hb during Oxygenation vs Deoxygenation.

The Amphoteric Response of Histidine Side ChainsA Modified Woolf-Augustinsson-Hofstee (WAH) Plot; Lineweaver-Burk Plot Adapted to Subtract Cooperativity; Dynamics of Ligands Modifying the Equilibrium of R to T State of the Quaternary Structure of Hemoglobin; A Mechanism for Hb-Deoxygenation at Neutral pH; The Role of BBB in Modulation of Red Cell Control of Hb Deoxygenation; Chapter 5: Enzyme-Membrane Systems; Mg2+ Treated-AC Particles Preparation from Cerebral Cortex; EDTA Treated-AC Particle Preparation from Cortex, Striatum and Hypothalamus; Mg2+ Requirement for Noradrenaline.

The fight-or-flight response could be characterized as a discretionary capability of choice, conditioned by learning that allows evolution to go beyond instinct. This book seeks to enlighten readers about the fight-or-flight response that is coupled by the body metabolic parameter of connectivity.

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