Autoimmunity versus carcinogenesis in tissue injury /Lawrence M. Agius.

Includes bibliographies and index.

"This book is a critical appraisal of the data and evidence available in literature of the relative roles of the immune response to neoplastic cells. An attempt has been made to render a better understanding of the various modes of impact of the immune response against tumors in general, particularly gliomas in some of the chapters. Autoimmune response is one mode of reactivity to native component cells within the body. Neoplastic transformation, on the other hand, critically necessitated the absence of an effective immune response to the transformed tumor cells in order for the lesion to grow and metastasize. This book is aimed towards a wider readership, but its particularly for oncologists and the various clinical and academic professionals that care for patients with cancer. It is especially meant to provide a clear exposition of known facts regarding the genesis and further development of neoplasms. Examples of some of the commoner lesions are accounted for"--

Intro -- Contents -- Preface -- Chapter 1 -- Predetermined Interplay of the Projected Malignant Transformation Step as Injury Non-Resolution -- Abstract -- Introduction -- Cell Death Pathways -- Identifiable Parameters of Progression -- Dyshomeostasis -- Pro-Apoptosis and Anti-Apoptosis -- Performance Attributes -- Conclusion -- References -- Chapter 2 -- Systems of Active Immune Suppression as Integral Malignant Transformation in Infiltrating Glioma Cells -- Abstract -- Introduction -- Cytokines -- Constitutional Factors -- Conditioned Settings -- Immune Response

Aberrant Immune Response -- Conclusion -- References -- Chapter 3 -- Systems of Failure of Immune Response to Early Carcinogenesis Recharacterize Such Early Carcinogenesis -- Abstract -- Introduction -- Incremental Evolution -- Stages of Emergence -- Immune Response -- Developmental Waves -- Modulation -- Conclusion -- References -- Chapter 4 -- Mirror Images of Geometric Pre-Setting of the Infiltrating Edges of High-Grade Gliomas -- Abstract -- Introduction -- Derivative Mechanisms -- System Injury Profiles -- Mirror Reproducibility -- Performance Requisites -- Conclusion -- References

Chapter 5 -- Failed Tumor Immuno-Antigenicity Is Expressed Suppression of an Autoimmunity in Defining Immune Privilege Status of the Lesion -- Abstract -- Introduction -- Interactivity -- Interplay Dynamics -- Variability of Antigenicity -- Lymphocyte Non-Reactivity -- Systems of Processing -- Immune Priviliged Status -- Conclusion -- References -- Chapter 6 -- Complex Effectiveness of General Immunity in Modulating the Specific Immune Response in Gliomas -- Abstract -- Introduction -- Antigen Presentation -- Immune System Specificity -- Potential Dynamics -- Series of Reactivities

Immune Response Increments -- Biology of Immunity -- Conclusion -- References -- Chapter 7 -- Systems of Malignant Transformation as Integral Immune Nonresponse in Gliomagenesis -- Abstract -- Introduction -- Injury to Glial Cells -- Performance of Tumors -- Induction of Maladaptation -- Proportional Correlates -- Infiltrated Brain Tissues -- Conclusion -- References -- Chapter 8 -- Immunodominance as Complex Patterned Interplay of Antigen Quantitation Phenomena in Pressure Immunity -- Abstract -- Introduction -- Demarcation Profiles of Antigenicity -- Immunodominance -- Antigenicity

Expressivity of Antigen -- Antigen Identity -- T Cell Specific Receptor -- Conclusion -- References -- Chapter 9 -- Systems of Unstable Immunodominance of Antigen as Formulas for Central Immunosuppression in Tumor Cell Expansion -- Abstract -- Introduction -- Tumor Dynamics -- Antigenicity -- Immunosurveillance -- Reformulations -- Facilitation -- Conclusion -- References -- Chapter 10 -- Failed Immunosurveillance as Failed Dendritic Cell Antigen Presentation-Substitution of Specific Tumor Antigenicity by Differentiation Associated Antigenicity -- Abstract -- Introduction -- Tumorigenesis

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