Antibody drug discovery /Clive R. Wood, editor.
Antibody drug discovery /Clive R. Wood, editor.
- London : Imperial College Press, (c)2012.
- 1 online resource (xv, 473 pages) : illustrations (some color)
- Molecular medicine and medicinal chemistry ; v. 4 .
Includes bibliographies and index.
Ch. 1. Humanization of antibodies / chapter 2. Selection and screening of antibody phage display libraries / chapter 3. Affinity maturation approaches for antibody lead optimization / chapter 4. Transgenic mice rearranging human antibodies / chapter 5. Isotype selection and Fc engineering: design and construction of fit-for-purpose therapeutic antibodies / chapter 6. Antibody expression from bacteria to transgenic animals / chapter 7. Current trends in antibody purification and lead selection / chapter 8. Design and application of immunoconjugates for cancer therapy / chapter 9. Dual-targeting bispecific antibodies as new therapeutic modalities for cancer / chapter 10. Antibody fragments and alternate protein scaffolds / Olivier Leger and Jose W. Saldanha -- David R. Buckler [and others] -- David Lowe, Trevor Wilkinson and Tristan J. Vaughan -- Sean Stevens -- William R. Strohl -- Paul Stephens and Berni M. Sweeney -- Jie Chen and Andrew Nixon -- Sherif El Sheikh [and others] -- Zhenping Zhu -- Lioudmila Tchistiakova [and others.
Monoclonal antibodies have become important treatments for cancer, inflammation and a wide range of other diseases, representing an increasing share of the most successful pharmaceutical markets. The technologies to discover these drugs have been developed by select centers of excellence in industry and academia, and are continually being fine tuned in the race to identify the best antibody-based drug candidates and accelerate their paths to patients. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field and to offer specialized perspectives to established researchers. The chapters set into context the significance of key developments and important considerations for selecting different approaches, such as antibody humanization, isotype selection, lead candidate selection criteria and protein production. All contributors to this work are experts in their fields and many have played pivotal roles in the creation of these technologies.
9781848166295
Immunoenzyme technique.
Antibody-drug conjugates.
Immunology--Technique.
Drug development.
Pharmaceutical biotechnology.
Immunoglobulins.
Electronic Books.
QP519 / .A585 2012
Includes bibliographies and index.
Ch. 1. Humanization of antibodies / chapter 2. Selection and screening of antibody phage display libraries / chapter 3. Affinity maturation approaches for antibody lead optimization / chapter 4. Transgenic mice rearranging human antibodies / chapter 5. Isotype selection and Fc engineering: design and construction of fit-for-purpose therapeutic antibodies / chapter 6. Antibody expression from bacteria to transgenic animals / chapter 7. Current trends in antibody purification and lead selection / chapter 8. Design and application of immunoconjugates for cancer therapy / chapter 9. Dual-targeting bispecific antibodies as new therapeutic modalities for cancer / chapter 10. Antibody fragments and alternate protein scaffolds / Olivier Leger and Jose W. Saldanha -- David R. Buckler [and others] -- David Lowe, Trevor Wilkinson and Tristan J. Vaughan -- Sean Stevens -- William R. Strohl -- Paul Stephens and Berni M. Sweeney -- Jie Chen and Andrew Nixon -- Sherif El Sheikh [and others] -- Zhenping Zhu -- Lioudmila Tchistiakova [and others.
Monoclonal antibodies have become important treatments for cancer, inflammation and a wide range of other diseases, representing an increasing share of the most successful pharmaceutical markets. The technologies to discover these drugs have been developed by select centers of excellence in industry and academia, and are continually being fine tuned in the race to identify the best antibody-based drug candidates and accelerate their paths to patients. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field and to offer specialized perspectives to established researchers. The chapters set into context the significance of key developments and important considerations for selecting different approaches, such as antibody humanization, isotype selection, lead candidate selection criteria and protein production. All contributors to this work are experts in their fields and many have played pivotal roles in the creation of these technologies.
9781848166295
Immunoenzyme technique.
Antibody-drug conjugates.
Immunology--Technique.
Drug development.
Pharmaceutical biotechnology.
Immunoglobulins.
Electronic Books.
QP519 / .A585 2012