Care, use, and welfare of marmosets as animal models for gene editing-based biomedical research : proceedings of a workshop /

Johnson, Anne Frances,

Care, use, and welfare of marmosets as animal models for gene editing-based biomedical research : proceedings of a workshop / Anne Frances Johnson and Lida Anestidou, rapporteurs ; Roundtable on Science and Welfare in Laboratory Animal Use, Institute for Laboratory Animal Research, Division on Earth and Life Studies, National Academies of Sciences, Engineering, Medicine. - Washington, DC : National Academies Press, (c)2019. - 1 online resource (1 PDF file (xii, 107 pages)) : illustrations

Includes bibliographical references.

Introduction -- Context for the use of marmosets as animal models -- Ethical considerations -- Current research applications -- Marmoset genomics and genetic diversity -- Marmoset care and management -- Final remarks -- Appendixes

The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.



9780309488518 9780309488525 9780309488549

101753860 DNLM


Marmosets as laboratory animals--Moral and ethical aspects--United States--Congresses.
Laboratory animals--Moral and ethical aspects--United States--Congresses.
Gene editing--Moral and ethical aspects--United States--Congresses.
Laboratory animals.
Callithrix.
Diseases--Animal models.
Animals, Laboratory
Callithrix
Disease Models, Animal
Animal Welfare
Biomedical Research--methods


Electronic Books.

QL737 / .C374 2019